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Showing 1–2 of 2 results
Advanced filters: Author: Zachary Hurd Clear advanced filters

  • Preterm birth (PTB) is the leading cause of perinatal mortality and newborn complications with limited treatment options. Here the authors show that dysregulation of bile acids increases risk for PTB in pregnant women while restoring bile acid homeostasis delays or prevents PTB in the mouse models.

    • Sangmin You
    • Ai-Min Cui
    • Ruitang Deng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Comprehensive analysis of epigenetic regulation demonstrates a series of complex, interacting chromatin mechanisms by which chronic exposure to opiates downregulates Bdnf gene transcription in the ventral tegmental area. This regulatory cascade is also shown to play a role in controlling opiate-induced behavioral plasticity.

    • Ja Wook Koo
    • Michelle S Mazei-Robison
    • Eric J Nestler
    Research
    Nature Neuroscience
    Volume: 18, P: 415-422