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Showing 1–6 of 6 results
Advanced filters: Author: Zachary Milne Clear advanced filters

  • We report that fatigue cracks in pure metals can undergo intrinsic self-healing; they were observed to heal by crack flank cold welding induced by local stress state and grain boundary migration.

    • Christopher M. Barr
    • Ta Duong
    • Brad L. Boyce
    Research
    Nature
    Volume: 620, P: 552-556

  • Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

    • Catherine M Phelan
    • Karoline B Kuchenbaecker
    • Paul D P Pharoah
    Research
    Nature Genetics
    Volume: 49, P: 680-691

  • To understand and predict friction, it is crucial to observe sliding at the nanoscale to uncover the mechanisms at play. Here, the authors show that nano-contacts exhibit strength near the ideal limit, and find that pull-off forces predicted by continuum models are reduced by shearing.

    • Takaaki Sato
    • Zachary B. Milne
    • Hiroyuki Fujita
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2.

    • Shahana Ahmed
    • Gilles Thomas
    • Douglas F Easton
    Research
    Nature Genetics
    Volume: 41, P: 585-590

  • AMP-activated protein kinase (AMPK) is shown to transcriptionally regulate genes involved in controlling energy metabolism in skeletal muscle by acting together with the NAD+-dependent deacetylase SIRT1. AMPK enhances SIRT1 activity by increasing cellular NAD+ levels, resulting in the deacetylation and activation of the SIRT1 downstream target PGC-1α.

    • Carles Cantó
    • Zachary Gerhart-Hines
    • Johan Auwerx
    Research
    Nature
    Volume: 458, P: 1056-1060