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Showing 1–3 of 3 results
Advanced filters: Author: Zaiming Jiang Clear advanced filters

  • PARP inhibitors are effective in cancer patients with BRCA1 mutations but whether this can extend to BRCA1 wildtype patients by targeting BRCA1 transcriptional regulation is unclear. Here, in preclinical models of pancreatic cancer, the authors identify OFD1 as a transcriptional regulator of BRCA1 via the DREAM complex and as a potential therapeutic target in combination with PARP inhibition.

    • Peng Li
    • Junjie Ye
    • Qing Zhong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • In this study, the authors report the structure-based discovery and preclinical evaluation of 2 simnotrelvir, an orally bioavailable 3CLpro inhibitor that blocks replication of SARS-CoV-2 variants in 3 vitro, shows robust efficacy in a mouse model and good safety and pharmacokinetic profiles in rats 4 and monkeys.

    • Xiangrui Jiang
    • Haixia Su
    • Yechun Xu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15