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Showing 1–3 of 3 results
Advanced filters: Author: Zainab Ahdash Clear advanced filters

  • Multidrug efflux pumps help bacteria survive stress and promote antibiotic resistance. Here, authors define the molecular detail of an anaerobic-connected pump MdtF uncovering acid-responsive activity which may enable toxin control in certain niches.

    • Ryan Lawrence
    • Mohd Athar
    • Eamonn Reading
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of this multidrug-resistance conferring pump.

    • Eamonn Reading
    • Zainab Ahdash
    • Argyris Politis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.

    • Sarah V. Faull
    • Andy M. C. Lau
    • Argyris Politis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13