In this study, the authors found that the transcriptional regulator myocyte enhancer binding factor 2 B (MEF2B) is an essential component of the BCL6 gene transcriptional complex and promotes diffuse large B-cell lymphoma (DLBCL) growth by inducing BCL6 expression. In addition to its regulatory role in DLBCL growth, MEF2B expression correlates positively with BCL6 and CD10 expression, and preferentially expressed in the germinal center B-cell-like DLBCL group.
- Siraj M. El Jamal
- Zakaria Grada
- Mohamed Hassan
