l-lactate is a key metabolite supporting neuronal activity, but methods to monitor l-lactate dynamics alongside neuronal activity in vivo have been limited. Here, authors report R-eLACCO2.1, a red fluorescent extracellular l-lactate biosensor enabling simultaneous, multiplexed imaging in awake mice.
- Yuki Kamijo
- Philipp Mächler
- Yusuke Nasu
