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Showing 1–5 of 5 results
Advanced filters: Author: Zara Sands Clear advanced filters

  • Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains the selectivity of this scaffold for D1R over other aminergic receptors and the mechanism of activating D1R.

    • Bingfa Sun
    • Dan Feng
    • Brian K. Kobilka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Hv1 voltage-gated proton channels lack a canonical pore domain and selectivity filter, suggesting the mechanism of permeation differs from other cation channels. Mutagenesis with conductance measurements coupled with molecular dynamics simulations now indicate that Hv1 has an internal water wire mediating selective H+ transport.

    • I Scott Ramsey
    • Younes Mokrab
    • David E Clapham
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 869-875