The authors carried out a comparative genetic and histopathological study of 15 patient-derived xenografts (PDX) that were newly established from patients with various types of aggressive non-Hodgkin lymphomas. We have demonstrated that despite keeping the same genetic profiles the PDX models do not recapitulate microenvironmental heterogeneity of the original lymphomas. These findings have implications on the relevance of PDX models in the context of preclinical research.
- Radek Jakša
- Jana Karolová
- Pavel Klener
