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Showing 1–2 of 2 results
Advanced filters: Author: Zeng-Fei Pei Clear advanced filters

  • Naturally occurring peptide–nucleobase hybrids are rare. Here Pei et al. report the discovery and biosynthetic studies of the first peptide–nucleobase hybrid catalyzed by an RRE–YcaO–dehydrogenase complex from a RiPP pathway, and show the biotransformation in a substrate-assisted manner.

    • Zeng-Fei Pei
    • Natalia M. Vior
    • Satish K. Nair
    Research
    Nature Chemical Biology
    Volume: 21, P: 143-154

  • Ribosomally synthesized and post-translationally modified peptides (RiPPs) are natural products with significant chemical complexity. Here, the authors identify the dehydrazoles, a class of hypermodified RiPPs with side chain dehydration and backbone heterocyclization, and identify enzymes involved in their biosynthesis and modifications.

    • Zeng-Fei Pei
    • Lingyang Zhu
    • Satish K. Nair
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13