Nature Search

The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages

Hu and Zhao et al. identify a mechanism mediated by CCL18 and RFX5, through which tissue macrophages adapt their metabolic programme to nutrient stress in the context of autoimmune diseases.

Zhaolan Hu
Tuantuan V. Zhao
Cornelia M. Weyand
Research23 Jun 2022
Nature Metabolism

Volume: 4, P: 759-774
Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice

The mechanisms underlying the chronic stress-induced increased risk for major depressive disorder and anxiety are unclear. Here, the authors show the transcriptional changes occurring in neocortical neurons and identify YY1 as a regulator of chronic stress-induced maladaptive behavior in mice.

Deborah Y. Kwon
Bing Xu
Zhaolan Zhou
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-19
Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

Rett syndrome (RTT) is caused by mutations in MeCP2. This study describes a new line of knock-in mutant mice that mimics a MeCP2 mutation found in individuals with RTT and recapitulates RTT-like phenotypes, including motor and cognitive impairments. These MeCP2 knock-in mice also have age-dependent abnormalities in audiogenic event-related neuronal information processing.

Darren Goffin
Megan Allen
Zhaolan Zhou
Research27 Nov 2011
Nature Neuroscience

Volume: 15, P: 274-283
Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects

Simultaneous single-cell profiling of 5hmC and 5mC shows their unique regulatory roles.

Emily B. Fabyanic
Peng Hu
Hao Wu
Research28 Aug 2023
Nature Biotechnology

Volume: 42, P: 960-974
Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease

Zhao et al. show that, in patients with coronary artery disease, CD4⁺ T cells present a blunted response to SARS-CoV-2 and Epstein–Barr viral antigens, due to the overexpression of the immune checkpoint CD155 in macrophages, primed by the exposure to low-density lipoprotein and its oxidized form. The experiments show that CD155 overexpression is due to stabilizing post-translational modifications mediated by the mRNA methylase MTTL3.

Tuantuan V. Zhao
Zhaolan Hu
Cornelia M. Weyand
Research13 Jul 2022
Nature Cardiovascular Research

Volume: 1, P: 634-648
Aging-associated HELIOS deficiency in naive CD4⁺ T cells alters chromatin remodeling and promotes effector cell responses

Goronzy and colleagues examine differences in naive CD4⁺ T cells from young and older adults to TCR stimulation. They find reduced HELIOS expression in the elderly, resulting in increased CD25 expression and activation of pSTAT5 in FOXP3⁻ T cells. This scenario favors generation of short-lived effector T cells over memory cell populations.

Huimin Zhang
Rohit R. Jadhav
Jörg J. Goronzy
Research12 Dec 2022
Nature Immunology

Volume: 24, P: 96-109
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Mitochondrial aspartate regulates ER morphology and co-translational translocation via BiP ADP ribosylation. In T cells from patients with rheumatoid arthritis, mitochondrial aspartate is deficient, resulting in ER expansion and excessive production of the pro-inflammatory cytokine TNF.

Bowen Wu
Tuantuan V. Zhao
Cornelia M. Weyand
Research22 Nov 2021
Nature Immunology

Volume: 22, P: 1551-1562
Study on the bearing performance of extra-long pile group foundation in accumulation slope under landslide effect

Zhaolan Wei
Chuanjiang Zhang
Shaomin Jia
ResearchOpen Access12 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways

Jiao Qin
Zhangzhe Peng
Lijian Tao
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-12

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