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Nature Immunology (2)

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Immunology

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Advanced filters: Author: Zhaoren He Clear advanced filters

Early transcriptional and epigenetic regulation of CD8⁺ T cell differentiation revealed by single-cell RNA sequencing

CD8⁺ T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity among responding lymphocytes, particularly at the first division, that influences cell fate.

Boyko Kakaradov
Janilyn Arsenio
Gene W Yeo
Research20 Feb 2017
Nature Immunology

Volume: 18, P: 422-432
Tissue-resident memory CD8⁺ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

Goldrath and colleagues define the diversity of gene expression and genome accessibility in mouse CD8⁺ T_RM cells in distinct tissues and identify molecules critical forgeneration of CD8⁺ T_RM cells in response to acute viral infection.

John T. Crowl
Maximilian Heeg
Ananda W. Goldrath
Research27 Jun 2022
Nature Immunology

Volume: 23, P: 1121-1131

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Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

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Early transcriptional and epigenetic regulation of CD8⁺ T cell differentiation revealed by single-cell RNA sequencing

Tissue-resident memory CD8⁺ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments