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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric G_s which offers insights into the molecular details of ago-allosterism.

Zhaotong Cong
Li-Nan Chen
Ming-Wei Wang
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-11
Structural basis for activation of the growth hormone-releasing hormone receptor

Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals a characteristic hormone recognition pattern of GHRH by GHRHR.

Fulai Zhou
Huibing Zhang
Ming-Wei Wang
ResearchOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1-10
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Multi-targeting agonists at GIPR, GLP-1R or GCGR are pursued vigorously. Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

Fenghui Zhao
Qingtong Zhou
Ming-Wei Wang
ResearchOpen Access25 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G_s proteins

Zhaotong Cong
Fenghui Zhao
Ming-Wei Wang
ResearchOpen Access13 Feb 2024
Cell Discovery

Volume: 10, P: 1-13
GPR160 is a potential biomarker associated with prostate cancer

Wanjing Guo
Junyu Zhang
Ming-Wei Wang
ResearchOpen Access25 Jun 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Wenbo Feng
Qingtong Zhou
Ming-Wei Wang
ResearchOpen Access31 Jul 2023
Cell Discovery

Volume: 9, P: 1-15
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

Wen Sun
Li-Nan Chen
Ming-Wei Wang
ResearchOpen Access25 Nov 2020
Cell Research

Volume: 30, P: 1098-1108
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

Wenzhuo Li
Qingtong Zhou
Ming-Wei Wang
CorrespondenceOpen Access17 Jul 2024
Cell Discovery

Volume: 10, P: 1-4
A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM

Yanyan Chen
Yang Li
Ming-Wei Wang
CorrespondenceOpen Access16 May 2024
Cell Discovery

Volume: 10, P: 1-4

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