Vitamin B2 metabolism is important for essential biological processes, such as protection against oxidative damage and facilitating the immune response. Here authors show that contrary to its protective role in other contexts, upregulated Vitamin B2 metabolism via flavin adenine dinucleotide synthase propels the growth of tumour cells in hepatocellular cancer, while suppressing the anti-tumour CD8+ T cell response.
- Jiashuo Chao
- Yuan Liang
- Ling Lu
