Nature Search

A bispecific antibody–drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial

In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

Chang Liu
Dan Liu
Zhihao Lu
ResearchOpen Access10 Jul 2025
Nature Medicine

Volume: 31, P: 3485-3491
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results

In the largest study so far of CAR T cells in patients with solid tumors, autologous CLDN18.2-targeting CAR T cell therapy was well tolerated in patients with advanced CLDN18.2-positive gastrointestinal cancers, with an overall response rate of 42.2% and a disease control rate of 91.1%.

Changsong Qi
Chang Liu
Lin Shen
Research03 Jun 2024
Nature Medicine

Volume: 30, P: 2224-2234
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results

In an interim analysis of a phase 1 trial, CAR T cells specific for Claudin18.2, a tight junction protein isoform highly expressed on gastrointestinal tract tumors, were well-tolerated and exhibited promising clinical activity in patients with gastrointestinal cancers.

Changsong Qi
Jifang Gong
Lin Shen
ResearchOpen Access09 May 2022
Nature Medicine

Volume: 28, P: 1189-1198
On the foundations of Earth foundation models

Foundation models could transform Earth sciences, according to a synthesis which identifies 11 key characteristics to be built into the ideal foundation model and provides recommendations for effective usage of the model and standardized evaluation criteria.

Xiao Xiang Zhu
Zhitong Xiong
Yilei Shi
ReviewsOpen Access08 Jan 2026
Communications Earth & Environment

Volume: 7, P: 1-16
TRIM35, a novel DNA-binding protein, epigenetically modifies H3 to promote HSPA6 transcription and suppress breast cancer progression

Xintao Jing
Fang Li
Chen Huang
ResearchOpen Access24 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-14
Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data

Zifan Chen
Yang Chen
Lin Shen
ResearchOpen Access26 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
Diagnosing pathologic myopia by identifying morphologic patterns using ultra widefield images with deep learning

Yang Liu
Keming Zhao
Jiansong Ji
ResearchOpen Access13 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-18
Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus

Ningjie Zhang
Yan Wang
Zheng Gong
ResearchOpen Access12 May 2025
Scientific Reports

Volume: 15, P: 1-14
A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer

Xi Jiao
Xin Wei
Lin Shen
ResearchOpen Access04 May 2021
npj Precision Oncology

Volume: 5, P: 1-9
Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3

Cui Liu
JunLei Wang
JianFeng Chen
Research19 Jul 2022
Oncogene

Volume: 41, P: 4091-4103

Search

Filter By:

Search

Quick links