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Showing 1–2 of 2 results
Advanced filters: Author: Zhengrong Zhangding Clear advanced filters

  • Depletion of cohesin subunit RAD21 increases DNA breaks genome-wide, leading to translocations at cancer-mutated hotspot genes. RAD21 depletion leads to dormant origin firing and induces irregular replication timing.

    • Jinchun Wu
    • Yang Liu
    • Jiazhi Hu
    Research
    Nature Genetics
    Volume: 55, P: 1347-1358

  • Emerging genome editing tools have been reported to possess threats to genome stability, while their impact on mitochondrial DNA (mtDNA) remains unknown. Here, authors report that genome editing of both nuclear and mitochondrial genome triggers transfer of mtDNA fragments into the nuclear genome.

    • Jinchun Wu
    • Yang Liu
    • Jiazhi Hu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12