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Showing 1–11 of 11 results

Advanced filters: Author: Zhenru Wu Clear advanced filters

Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner

Obesity and related metabolic disorders have become a global epidemic. Here, authors reveal that arginase 1 drives hepatic lipid production via a non-enzymatic interaction with ERK2, offering a promising therapeutic target for metabolic diseases.

Mingyang Shao
Xiaoyue Cao
Yujun Shi
ResearchOpen Access18 Feb 2026
Nature Communications

Volume: 17, P: 1-19
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

Han and colleagues reveal that the phosphatase Ppm1b dephosphorylates the kinase Rip3 to negatively regulate necroptosis in vitro and in vivo.

Wanze Chen
Jianfeng Wu
Jiahuai Han
Research09 Mar 2015
Nature Cell Biology

Volume: 17, P: 434-444
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

Jun Wu
Jingsheng Yuan
Jiayin Yang
ResearchOpen Access07 Nov 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15
Loss of NUMB promotes hepatomegaly and hepatocellular carcinoma through the AKT/glycogen/hippo signaling

Yuke Shu
Qing Tao
Yujun Shi
Research03 May 2025
Oncogene

Volume: 44, P: 2574-2587
RBM39 promotes hepatocarcinogenesis by regulating RFX1’s alternative splicing and subsequent activation of integrin signaling pathway

Bo Zhang
Yongjie Zhou
Jiayin Yang
Research03 Mar 2025
Oncogene

Volume: 44, P: 1488-1503
UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism

Zhenru Zhu
Chuanhui Cao
Jingyuan Sun
ResearchOpen Access15 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-13
c-Kit⁺ cells that intercalate with crypt Lgr5⁺ cells are distinctively multipotent in colonic epithelium renewal and repair

Qing Xu
Yuting Zeng
Yujun Shi
Research07 Mar 2025
Cell Death & Differentiation

Volume: 32, P: 1244-1258
miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma

Hao Wu
Wei Zhang
Changan Liu
ResearchOpen Access18 Jan 2019
Cell Death & Disease

Volume: 10, P: 1-18
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling

Ping Yin
Dan Li
Li Su
ResearchOpen Access14 Dec 2021
Cell Death Discovery

Volume: 7, P: 1-12
Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling

Yuke Shu
Qing Xu
Hong Bu
ResearchOpen Access19 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-11
The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation

Lisheng Li
Wanze Chen
Jiahuai Han
Research11 Feb 2014
Cell Research

Volume: 24, P: 417-432