Li et al develop an algorithm they call Deviating gene Expression Profiling Tumor Heterogeneity (DEPTH) to evaluate levels of intratumour heterogeneity (ITH) at the mRNA level based on the asynchrony of transcriptome alterations in tumors. Analysing TCGA and GEO data-sets, they show that this method is simpler, more effective, and more robust than other ITH scoring algorithms.
- Mengyuan Li
- Zhilan Zhang
- Xiaosheng Wang
