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Showing 1–8 of 8 results

Advanced filters: Author: Zhuchi Tu Clear advanced filters

Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease

A Cas9-based gene therapy that replaces expanded CAG repeats in the mutant HTT allele causing Huntington’s disease by a normal CAG repeat led to substantial reductions in neurological symptoms in a pig model of the disease.

Sen Yan
Xiao Zheng
Shihua Li
Research16 Feb 2023
Nature Biomedical Engineering

Volume: 7, P: 629-646
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

Zhuchi Tu
Weili Yang
Xiao-Jiang Li
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Zhuchi Tu
Sen Yan
Xiao-Jiang Li
ResearchOpen Access22 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-13
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Bang Li
Hui Zhao
Xiao-Jiang Li
ResearchOpen Access07 Mar 2023
Cell Discovery

Volume: 9, P: 1-23
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

Hui Zhao
Zhuchi Tu
Yong Q Zhang
Correspondence25 Jul 2017
Cell Research

Volume: 27, P: 1293-1297
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Zheng Xiao
Huang Chunhui
Sen Yan
ResearchOpen Access04 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-13
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Hui Zhao
Qiqi Wang
Yong Q. Zhang
ResearchOpen Access21 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-13
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys

Weili Yang
Yunbo Liu
Xiao-Jiang Li
CorrespondenceOpen Access15 Feb 2019
Cell Research

Volume: 29, P: 334-336