The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. The SEC controls transcription elongation in the presence or absence of promoter-proximal paused Pol II, and its gene target specificity depends on protein components forming distinct SEC complexes.
- Zhuojuan Luo
- Chengqi Lin
- Ali Shilatifard
