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Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Ash1 is an H3K36 methyltransferase, Trithorax group protein and is critical in antagonizing Polycomb silencing. Here, the authors purify the Drosophila Ash1 complex and identify Mrg15 and Nurf55 as subunits, finding that Mrg15 is recruited by Ash1 and reinforces Ash1 activity.

Chang Huang
Fu Yang
Bing Zhu
ResearchOpen Access21 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Targeting pericentric non-consecutive motifs for heterochromatin initiation

Zinc-finger proteins ZNF512 and ZNF512B are shown to target pericentric DNA through a conserved mechanism that depends on their atypical long linkers, providing insight into how constitutive heterochromatin formation is initiated across various species.

Runze Ma
Yan Zhang
Bing Zhu
Research03 Jul 2024
Nature

Volume: 631, P: 678-685
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA

This study identifies a family of protein, MARTRE, as regulators of poly(A) tail length in early mouse embryos. MARTREs inhibit CCR4-NOT complex-mediated deadenylation, ensuring efficient translation of maternal mRNA for embryo development.

Jing Yang
Jiachen Bu
Yingfeng Li
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-23
Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation

Epigenetic reprogramming involves global loss of DNA methylation, but how this is regulated is not completely understood. Here, Tan et al. run a reverse genetic screen and report that nuclear DNMT1 is finetuned by maternal factor Pramel15 through proteasomal degradation in mouse zygotes.

Jiajun Tan
Yingfeng Li
Bing Zhu
ResearchOpen Access25 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1

Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.

Yingfeng Li
Zhuqiang Zhang
Bing Zhu
Research28 Nov 2018
Nature

Volume: 564, P: 136-140
Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

The crystal structure of Drosophila melanogaster YL1 in complex with an H2A.Z–H2B dimer exposes a selective recognition mechanism distinct from those of other H2A.Z chaperones and suggests a hierarchical transfer mechanism mediating H2A.Z deposition.

Xiaoping Liang
Shan Shan
Zheng Zhou
Research14 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 317-323
Author Correction: Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration

Xuan Ming
Zhuqiang Zhang
Bing Zhu
Amendments and Corrections26 Jan 2021
Cell Research

Volume: 31, P: 373
Establishing a clinical prediction model for diabetic foot ulcers in type 2 diabetic patients with lower extremity arteriosclerotic occlusion using machine learning

Yubo Wang
Chunyu Jiang
Shouyu Wang
ResearchOpen Access05 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration

Xuan Ming
Zhuqiang Zhang
Bing Zhu
Research24 Jun 2020
Cell Research

Volume: 30, P: 980-996
Polymerase iota (POLI) confers radioresistance of esophageal squamous cell carcinoma by regulating RAD51 stability and facilitating homologous recombination

Xiaoqing Li
Dexuan Gao
Ji Zhu
ResearchOpen Access09 Aug 2023
Cell Death Discovery

Volume: 9, P: 1-10
Simultaneously measuring the methylation of parent and daughter strands of replicated DNA at the single-molecule level by Hammer-seq

This protocol combines nascent DNA labeling, hairpin adapter ligation and bisulfite sequencing to simultaneously measure the methylation state of parent and daughter strands of replicating DNA, permitting assessment of maintenance and de novo methylation.

Xuan Ming
Bing Zhu
Zhuqiang Zhang
Protocols08 Mar 2021
Nature Protocols

Volume: 16, P: 2131-2157
Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis

Yujian Wu
Xiangjing Hu
Chunsheng Han
ResearchOpen Access08 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase

Hong Nian
Wei Zhang
Chunsheng Han
Correspondence24 Jun 2008
Cell Research

Volume: 18, P: 800-802
Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway

Ming Ni
Jiannan Qiu
Qiang Zhu
ResearchOpen Access15 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-14
SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization

Hang Fu
Nan Liu
Bing Zhu
Correspondence10 Jan 2019
Cell Research

Volume: 29, P: 254-257
Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z

Zhuo Mao
Lu Pan
Zheng Zhou
ResearchOpen Access11 Mar 2014
Cell Research

Volume: 24, P: 389-399

Search

Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Targeting pericentric non-consecutive motifs for heterochromatin initiation

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation

Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1

Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

Author Correction: Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration

Establishing a clinical prediction model for diabetic foot ulcers in type 2 diabetic patients with lower extremity arteriosclerotic occlusion using machine learning

Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration

Polymerase iota (POLI) confers radioresistance of esophageal squamous cell carcinoma by regulating RAD51 stability and facilitating homologous recombination

Simultaneously measuring the methylation of parent and daughter strands of replicated DNA at the single-molecule level by Hammer-seq

Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis

Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase

Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway

SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization

Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z

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