USP22 overexpression in macrophages alleviates atherosclerosis in ApoE-/- mice. USP22 silencing enhances macrophage inflammation, foam cell formation, and impairs efferocytosis. Mechanistically, USP22 stabilizes PPARγ to promote efferocytosis.
- Senhu Tang
- Chuanghong Lu
- Zhiyu Zeng