The lack of stable and versatile bicyclo[1.1.1]pentyl reagents hinders their broader adoption as aryl bioisosteres in drug discovery. Now, a stable, bifunctional iodobicyclo[1.1.1]pentylmethyl thianthrenium (IBM-TT+) reagent is developed for modular bicyclo[1.1.1]pentane bioisostere production.
- Zibo Bai
- Zikuan Wang
- Tobias Ritter
