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Showing 1–4 of 4 results
Advanced filters: Author: Zile Zhu Clear advanced filters
  • Despite the established C − H deuteration of pyridine derivatives synthetic methods with good D-incorporation, under milder conditions with easy operation procedures is still on the way. Here, the authors develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C − H deuteration of pyridine derivatives with high selectivity and excellent D-incorporation at room temperature, which use D2O as economic and convenient D-source.

    • Zhiwei Zhao
    • Ranran Zhang
    • Youai Qiu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9
  • Electrochemical cross-electrophile coupling with alkyl halides for the construction of C(sp3)–C(sp3) bonds is generally limited to activated alkyl halides. Now this approach is extended to coupling of unactivated alkyl halides using a nickel catalyst under mild conditions.

    • Pengfei Li
    • Zile Zhu
    • Youai Qiu
    Research
    Nature Catalysis
    Volume: 7, P: 412-421
  • Peptide aldehydes are an important class of biomolecules, playing essential roles in various living systems, and there is an ongoing demand for the efficient synthesis of peptide aldehydes. Herein, the authors report the electrooxidative ring-opening reaction via C‒N bond cleavage for the synthesis of unnatural peptide aldehydes.

    • Xinyue Fang
    • Yong Zeng
    • Zhixiong Ruan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10