Nature Search

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K⁺ and maintains axonal health

Looser et al. reveal that oligodendrocytes detect and respond to axonal activity using K⁺ signaling to regulate vital metabolic support and maintain axon health.

Zoe J. Looser
Zainab Faik
Aiman S. Saab
ResearchOpen Access24 Jan 2024
Nature Neuroscience

Volume: 27, P: 433-448
Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke

Glucose uptake in astrocytes is thought to rely on GLUT1. Here, the authors show that adult mice tolerate astrocyte-specific GLUT1 deletion, which increases astrocytic glucose metabolism and confers neuroprotection in a model of stroke.

Laetitia Thieren
Henri S. Zanker
Aiman S. Saab
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-15
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be an energy reserve for white matter axons, supporting their function.

Ebrahim Asadollahi
Andrea Trevisiol
Klaus-Armin Nave
ResearchOpen Access09 Sept 2024
Nature Neuroscience

Volume: 27, P: 1934-1944
Microclimate governs the morphology of sediment flows on Mars

Gravitational flow deposits on Earth may not be meaningful analogues for those on Mars or other planetary bodies according to laboratory experiments conducted at Mars-like temperatures and pressures where freezing and evaporative cooling play key roles.

Jacob B. Adler
Frances Rivera-Hernández
Mark Fox-Powell
ResearchOpen Access24 Oct 2025
Communications Earth & Environment

Volume: 6, P: 1-8
Arousal-induced cortical activity triggers lactate release from astrocytes

Zuend and colleagues show that an arousal-induced increase in cortical activity is accompanied by a surge in lactate in the extracellular space and a substantial lactate dip in astrocytes, followed by mobilization of lactate from glycogen stores and neuronal lactate increase.

Marc Zuend
Aiman S. Saab
Bruno Weber
Research17 Feb 2020
Nature Metabolism

Volume: 2, P: 179-191
Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Ebrahim Asadollahi
Andrea Trevisiol
Klaus-Armin Nave
Amendments and CorrectionsOpen Access17 Sept 2024
Nature Neuroscience

Volume: 27, P: 2046
Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors

Recombination during AAV production disrupts gene delivery in vivo. We present ABCD, a codon diversification strategy that prevents recombination, enabling reliable quantitative imaging using FRET sensors and gene expression in living animals.

Jan Dernic
Afroditi Eleftheriou
Luca Ravotto
ResearchOpen Access19 Aug 2025
Communications Biology

Volume: 8, P: 1-14
Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland

Calum Macdonald
Norah Palmateer
Josie Murray
ResearchOpen Access14 Jun 2024
npj Vaccines

Volume: 9, P: 1-12

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