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Advanced filters: Author: Zon Weng Lai Clear advanced filters

Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition

Multidrug efflux pump EfpA is an essential protein for M. tuberculosis. The authors determine the structures of MtEfpA bound to lipids or the inhibitor BRD-8000.3, and propose it may function as a lipid flippase with a defined inhibition mechanism.

Shuhui Wang
Kun Wang
Maofu Liao
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Identification of two pathways mediating protein targeting from ER to lipid droplets

Song et al. identify two protein-targeting pathways from the endoplasmic reticulum to (1) early lipid droplets (LDs) and (2) mature lipid droplets. They define key factors mediating the second, late pathway and its many cargoes.

Jiunn Song
Arda Mizrak
Tobias C. Walther
ResearchOpen Access01 Sept 2022
Nature Cell Biology

Volume: 24, P: 1364-1377
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets

Chung et al. identify the protein spartin, linked to Troyer syndrome, as a lipophagy receptor for lipid droplet clearance in vitro and in vivo. The data suggest that impaired lipid droplet turnover may contribute to Troyer syndrome development.

Jeeyun Chung
Joongkyu Park
Robert V. Farese Jr.
ResearchOpen Access13 Jul 2023
Nature Cell Biology

Volume: 25, P: 1101-1110