Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Zunlong Ke Clear advanced filters

  • Here, combining X-ray crystallography, cryo-electron tomography and animal studies, the authors show that the monoclonal antibody against Ebola virus glycoprotein (GP1,2) 3A6 exerts protection via binds to a conformation of GP1,2 that is lifted from the virion membrane, providing insights into the mechanism of action with implications for the design of anti-Ebola therapeutics.

    • Kathryn M. Hastie
    • Zhe Li Salie
    • Erica Ollmann Saphire
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Here the authors use cryo-electron tomography and sub-tomogram averaging to determine the molecular organization of RSV. The structures show that the matrix (M) protein packs as a helical-like lattice and the F glycoprotein is present as anti-parallel pairs of trimers and coordinates with the M lattice.

    • Bryan S. Sibert
    • Joseph Y. Kim
    • Elizabeth R. Wright
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Cryo-electron microscopy and tomography studies reveal the structures, conformations and distributions of spike protein trimers on intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions and provide a basis for understanding the interactions of the spike protein with neutralizing antibodies.

    • Zunlong Ke
    • Joaquin Oton
    • John A. G. Briggs
    Research
    Nature
    Volume: 588, P: 498-502

  • Virus assembly is technically challenging to study. Here the authors use cryo-electron tomography of measles virus-infected human cells to determine native-state virus structure and they locate well-ordered M lattices that organize viral glycoproteins, RNP, and drive assembly.

    • Zunlong Ke
    • Joshua D. Strauss
    • Elizabeth R. Wright
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between open and closed conformations. Disulfide bonds are engineered into the spike ectodomain to lock the RBD in the closed state, leading to a construct with high thermostability.

    • Xiaoli Xiong
    • Kun Qu
    • John A. G. Briggs
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 934-941