Nature Search

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence

Liping Deng
Ruotong Ren
Guang-Hui Liu
ResearchOpen Access26 Jul 2019
Nature Communications

Volume: 10, P: 1-16
m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging

The authors characterized m⁶A dynamics in primate tissue aging and revealed a new role for the METTL3–m⁶A–NPNT axis in maintaining skeletal muscle homeostasis, thereby providing insight into the epitranscriptomic machinery underlying primate aging.

Zeming Wu
Mingming Lu
Guang-Hui Liu
Research06 Apr 2023
Nature Aging

Volume: 3, P: 705-721
SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B

Ye et al. characterize the cardioprotective effect of SIRT2 in primates and reveal an important role for the SIRT2–STAT3–CDKN2B regulatory axis in primate cardiac aging, improving understanding of the epigenetic mechanism governing cardiac aging.

Yanxia Ye
Kuan Yang
Guang-Hui Liu
Research02 Oct 2023
Nature Aging

Volume: 3, P: 1269-1287
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.

Weiqi Zhang
Haifeng Wan
Baoyang Hu
Research22 Aug 2018
Nature

Volume: 560, P: 661-665
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Zunpeng Liu
Wei Li
Guang-Hui Liu
ResearchOpen Access01 Feb 2022
Cell Discovery

Volume: 8, P: 1-22
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

Chuqian Liang
Zunpeng Liu
Guang-Hui Liu
ResearchOpen Access31 Jul 2020
Cell Research

Volume: 31, P: 187-205
SGF29 nuclear condensates reinforce cellular aging

Kaowen Yan
Qianzhao Ji
Guang-Hui Liu
ResearchOpen Access07 Nov 2023
Cell Discovery

Volume: 9, P: 1-21
Author Correction: SGF29 nuclear condensates reinforce cellular aging

Kaowen Yan
Qianzhao Ji
Guang-Hui Liu
Amendments and CorrectionsOpen Access15 Feb 2025
Cell Discovery

Volume: 11, P: 1-4
Publisher Correction: SGF29 nuclear condensates reinforce cellular aging

Kaowen Yan
Qianzhao Ji
Guang-Hui Liu
Amendments and CorrectionsOpen Access30 May 2024
Cell Discovery

Volume: 10, P: 1
Effects of disc overhang diameter on the uplift bearing capacity of new-type concrete expanded-plate pile groups

Yongmei Qian
Mingyue Che
Kai Zhang
ResearchOpen Access12 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Single-cell transcriptomic atlas of primate cardiopulmonary aging

Shuai Ma
Shuhui Sun
Guang-Hui Liu
ResearchOpen Access10 Sept 2020
Cell Research

Volume: 31, P: 415-432

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Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging

SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

SGF29 nuclear condensates reinforce cellular aging

Author Correction: SGF29 nuclear condensates reinforce cellular aging

Publisher Correction: SGF29 nuclear condensates reinforce cellular aging

Effects of disc overhang diameter on the uplift bearing capacity of new-type concrete expanded-plate pile groups

Single-cell transcriptomic atlas of primate cardiopulmonary aging

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