Treg cells play a pivotal role in suppressing allograft rejection but their presence in tumours hamper antitumour immunity. Here authors show that T cells, in which Setdb1 is genomically deleted, give rise to Treg cells that prevent allograft rejection but don’t compromise the antitumour immune response.
- Xiaosheng Tan
- Xiangli Zhao
- Peixiang Lan
