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Showing 1–6 of 6 results
Advanced filters: Author: Zvulun Elazar Clear advanced filters

  • Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy.

    • Ana Maria Cuervo
    • Zvulun Elazar
    • Shuhei Nakamura
    Reviews
    Nature Cell Biology
    Volume: 26, P: 661-666

  • Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.

    • Amir Gelman
    • Moran Rawet-Slobodkin
    • Zvulun Elazar
    News & Views
    Nature Cell Biology
    Volume: 17, P: 214-215

  • Disease-associated mutations in the protein TECPR2 have so far been mainly studied with respect to autophagy. Using complementary proteomics approaches, the authors identify trafficking and sorting defects along the secretory pathway upon TECPR2 deficiency and provide evidence that TECPR2 associates with the ER-Golgi interface.

    • Karsten Nalbach
    • Martina Schifferer
    • Christian Behrends
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Autophagy is a process of cellular self-consumption that promotes cell survival in response to stress. Various human pathologies, including cancer, neurodegeneration and inflammation, have been associated with aberrant autophagy, and recent studies of the mechanisms and regulation of autophagy in higher eukaryotes have suggested new therapeutic possibilities.

    • Ivan Dikic
    • Zvulun Elazar
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 349-364