Alzheimer's disease articles from across Nature Portfolio

Using advanced MRI modeling, this study found distinct spatial and pathophysiological signatures in vascular- and neurodegeneration-related white matter hyperintensities, clarifying their interpretation using clinically translatable methods.

Hajjar et al. investigate whether proteins involved in cardiometabolic and inflammatory pathways can identify people who will develop Alzheimer’s disease before symptoms appear. A group of proteins linked to endothelial function are elevated even in early, symptom-free stages and predict disease progression.

Using nasal brush biopsies from the olfactory region, single-cell profiling revealed neuroimmune alterations in Alzheimer’s Disease detectable at a pre-clinical stage, offering an accessible window into early neurodegenerative disease in humans.

In the phase 3 EVOKE(+) trials, semaglutide did not slow clinical progression of Alzheimer’s disease, but the findings provide new insights in the ongoing quest for treatments.

Single-nucleus sequencing reveals age- and disease-related changes in the molecular regulation of neurogenesis associated with cognitive decline and resilience.

When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

The country is facing a coming wave of dementia for its ageing population, and is investing in research into drugs, diagnostics and even surgery to prepare itself.

Researchers show that in mice, tumor-secreted cystatin-C crosses the blood–brain barrier and stimulates microglia to degrade amyloid plaques, which opens interesting avenues for translational clinical studies.