Cancer prevention articles from across Nature Portfolio

Tumours with alterations in SWI/SNF complex have elevated EZH2 activity, which is associated with poor prognosis and tumour progression. Here, the authors report a phase 2 basket study investigating the safety and efficacy of oral tazemetostat (EZH2 inhibitor) in patients with solid tumours harbouring SWI/SNF driver mutations.

Cervical cancer is a largely preventable disease that yet has a high burden and mortality rate in Africa. In here the authors review, the advancement in cervical cancer screening, treatment, and prognosis and advocate for decisive measures to enhance screening methods

Mutant haematopoietic stem cells display broad fitness variation, suggesting that protective mechanisms may limit clonal expansion and malignant transformation. Now, Agarwal et al. identify a germline noncoding variant that confers resilience to clonal haematopoiesis of indeterminate potential (CHIP) by dampening expression of the RNA-binding protein MSI2.

This Focus issue highlights current research at the intersection of ageing and cancer, and explores how insights gained from this may lead to better cancer prevention strategies and diagnostics, enhanced therapeutic efficacy and improvements to both patient quality of life and outcomes.

Glucagon-like peptide-1 (GLP-1) receptor agonists are widely prescribed for weight loss. Here, Hebert and colleagues discuss the need for long-term studies assessing the impacts of this on muscle mass and nutritional deficiencies, which may influence cancer susceptibility and metabolic health.

Recent extreme weather events have impacted communities once considered safe from climate hazards, posing growing challenges to cancer control efforts. Here, Nogueira and Salas argue that the oncology community urgently needs to prioritize solution-focused adaptation and mitigation actions.