Cell death and immune response articles from across Nature Portfolio

This Review presents the formation of large extracellular vesicle (L-EV) subsets, highlighting that their contents and physiological relevance, for example, in intercellular communication, are driven by the different mechanisms underlying their biogenesis.

How different types of cell death influence cellular regeneration is unclear. Here, the authors profile transcriptional immune and support cell injury responses to different hair cell death modalities using scRNA-seq. Notably, blocking immune cells differentially affects regenerative outcomes depending on the cell death context.

Ferroptosis is a form of programmed immunogenic cell death (ICD) that has gained increasing attention in cancer immunotherapy. In this study, we present dendritic cell vaccines loaded with ferroptotic tumor lysates to enhance antitumoral immune response in glioma models.

This Review compares the structure–function relationships of the apoptosome, inflammasomes and PIDDosome, which are the three main platforms activating the CARD-containing caspases caspase-9, caspase-1 and caspase-2, respectively. It highlights the consequences of genetic perturbations of these platforms and their therapeutic potential in humans.

We developed a nanoadjuvant platform that targets early endosome membranes in tumour cells, triggering their pyroptosis and the release of pyroptosomes, which act as an in situ vaccine against the tumour. In preclinical cancer models featuring multiple metastases, this nanoplatform enabled spatiotemporal induction of robust immune responses, resulting in systemic tumour eradication and long-lasting antitumour immunity.

A study by Liu et al. identifies GPX4 as an immunosuppressive mediator released by ferroptotic tumour cells that inhibits the antitumour response.