Clinical microbiology articles from across Nature Portfolio

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation. This study shows that gut microbiota dysbiosis disrupts keratinocyte lipid metabolism via the bile acid–FXR–NQO1 pathway, supporting microbiota-targeted therapeutic approaches.

Parkin et al., using metagenomic sequencing, this double-blinded RCT compared gut microbiomes of infants given dechlorinated or chlorinated drinking water for 12 months. Overall composition was similar, but chlorinated water was linked to enriched antibiotic-resistance functions, especially with antibiotic use, suggesting early-life selective pressures.

Here the authors develop a machine-learning tool (MALCA) that uses inhibition zone diameters from routine disc diffusion tests to directly detect carbapenemase-producing Enterobacterales and identify the carbapenemase type with high accuracy, enabling earlier targeted treatment without additional laboratory resources.

This study highlights the role of the gut microbiome in shaping drug–drug interactions, with implications for treatment efficiency and patient outcome.

Locally relevant use cases can maximize national support for genomic sequencing in low- and middle-income countries.

This study reports the structure, specificity and genotoxic activity of colibactin.

This study shows that regional mismatches between transplanted microbiota and the host gut environment alter the metabolic and immune states of host tissues as well as the composition of regional microbiomes.

Microbial-based and microorganism-targeting therapies are emerging to prevent or treat preterm infant complications, but more preclinical research and clinical evidence is needed.