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A human eye disease seems to be linked to covert mortality nodavirus, a virus commonly found in aquatic animals. The findings suggest that zoonotic transmission to humans occurs through close contact.
Pathological neovascularization is a leading cause of vision loss. In this study, the authors identify FRZB and its NTR domain as suppressors of ocular angiogenesis. FRZB prevents CAV1 phosphorylation at Tyr42 which enhances downstream TGFβ signaling via ALK5 retention.
A human eye disease seems to be linked to covert mortality nodavirus, a virus commonly found in aquatic animals. The findings suggest that zoonotic transmission to humans occurs through close contact.
