Fibromyalgia articles from across Nature Portfolio

Psychological symptoms have a pivotal role in determining the severity of fibromyalgia. Findings now show that identifying and managing these symptoms during the early stages of disease could reveal disease phenotypes and improve the management of fibromyalgia.

Fibromyalgia remains a challenge for researchers and clinicians. Three studies published in 2025 shed light on mechanisms and management by implicating gut microbiota in symptom perpetuation, demonstrating the potential of home-based neuromodulation, and examining the uncertain role of low-dose naltrexone.