Gastric cancer articles from across Nature Portfolio

As presented at the 2026 ASCO Annual Meeting, in a phase 2 trial that included an exploratory and a pivotal phase, treatment of patients with MET-amplified gastric or gastroesophageal junction adenocarcinoma with the selective MET tyrosine kinase inhibitor savolitinib showed promising clinical efficacy.

Nuclear KRT19 drives gastric cancer metastasis by activating the NF-κB-FSCN1 axis, revealing how an intermediate filament rewires transcriptional and cytoskeletal programs to promote tumor cell motility.

The management of gastro-oesophageal adenocarcinoma (GEA) is undergoing substantial changes owing to evolving treatment paradigms and new therapeutic strategies on the background of a shifting global epidemiology. This Review discusses the state-of-the-art perioperative management of resectable GEA, with an emphasis on how biological heterogeneity influences geographical practice patterns, and outlines future directions for research including precision medicine approaches, biomarker-guided immunotherapy and tailored surgical approaches.

Spatial transcriptomics identifies the IM-crypt as a premalignant niche driving divergence between complete and incomplete intestinal metaplasia and shaping distinct transcriptional programs in early gastric cancer.

Gastric and gastroesophageal junction adenocarcinoma remains a major global health challenge, with a rising incidence among younger individuals worldwide despite advances in biomarker-directed targeted therapies and immunotherapy. Current breakthroughs include perioperative immunotherapy, HER2-directed therapy sequencing and a decisive shift towards biomarker-driven treatment.

A pair of phase 1 trials evaluating antibody–drug conjugates identify potential strategies to treat advanced gastroesophageal cancers and highlight the rapid expansion of claudin18.2-targeting drug development in solid tumors.

Gastric cancer is often overlooked in the United States, yet East Asian and other immigrant communities face a markedly increased burden. A community-based, migration-informed approach is needed to strengthen prevention and reduce disparities.