Haematopoietic system articles from across Nature Portfolio

This Review provides an overview of how platelets promote immunothrombosis in rheumatic disease. The authors discuss the different ways in which platelets and immunothrombosis can be targeted for therapeutic intervention.

Microenvironmental niches are instrumental to immune cell development via supporting soluble and contact-dependent differentiation signals. Here authors show that different bone marrow mesenchymal stromal cell subtypes modulate NK cell development via their different Il-15 expression capacities.

A vascularized bone-marrow-on-a-chip incorporating patient-derived CD34⁺ cells recapitulates haematopoietic defects associated with bone-marrow injury.