Health care articles from across Nature Portfolio

Evidence for the effectiveness of exercise in osteoarthritis, particularly the long-term benefit, remains unclear. Now, a review of current evidence suggests that the benefits could be negligible. This finding raises an important question: should exercise therapy continue to be recommended as a first-line treatment for osteoarthritis?

A regional analysis brought together data on wild-animal consumption by more than 12,000 households, to investigate trends and drivers of wild-meat use across Central Africa. The study found that consumption has increased over the past two decades, and that the increase was driven by demand from growing towns and cities.

In people with advanced skin cancer, injecting low doses of an anticancer immunotherapy directly into tumours, rather than administering high doses intravenously, reduced severe immune toxicity while preserving antitumour efficacy. Pre-existing antitumour immunity predicted clinical benefit most strongly, and profiling fresh tissue provided response biomarkers faster than conventional diagnostics did.

Burnout is a systemic problem, but individuals can take steps to cope with it and pave a path forward.

Artificial intelligence is rapidly being adopted in healthcare, but studies have shown a ‘deskilling’ phenomenon. Routine exposure to medical artificial intelligence can pose deskilling risks for physicians. We discuss these risks and whether such systems violate the European Union Artificial Intelligence Act, the world’s first comprehensive regulatory framework on artificial intelligence.

Evidence for the effectiveness of exercise in osteoarthritis, particularly the long-term benefit, remains unclear. Now, a review of current evidence suggests that the benefits could be negligible. This finding raises an important question: should exercise therapy continue to be recommended as a first-line treatment for osteoarthritis?

Some clinicians are pushing to broaden testosterone use, but there is debate about its benefits and risks.