Long-term depression articles from across Nature Portfolio

Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling through the claustrum, a brain region involved in regulating cognition and brain network states.

Endocannabinoids are important modulators of synaptic transmission, although their mechanism of release is unknown. In this study, the authors found that endocannabinoid postsynaptic release is mediated by synucleins via a synuclein-dependent and SNARE-dependent mechanism.

The synaptic protein SynGAP exerts its effects on synaptic plasticity via a structural role rather than its GTPase-activating protein activity.

Activation of microglial complement receptor 3 by an inflammatory stimulus in the presence of hypoxia induces long-term depression of synaptic transmission in the hippocampus.