Neuropathic pain articles from across Nature Portfolio

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Nav1.7 is a threshold current generator. Here, authors show that Thr1398 underlies the low voltage dependence of hNav1.7, determines its function as a threshold channel. This low-voltage dependence may be exploited to develop Nav1.7 selective inhibitors for pain therapy.

Spinal cord stimulation is seen as a last-resort therapy for the treatment of chronic pain. Controversies surrounding the treatment might be addressed through collaborative efforts to conduct innovative clinical trials and reach consensus on treatment guidelines.

A new report shows that chronic pain leads to accumulation of pathological forms of tau protein in the hippocampus, resulting in neuronal atrophy and cognitive impairment.