Radiotherapy articles from across Nature Portfolio

Precise transcription-repair coordination is required for efficient DSB repair. Here, the authors show that DNA-PK-mediated CRTC2 Ser433 phosphorylation, relocates DNA-PK from transcription to repair complexes and promote NHEJ. Inhibition of CRTC2 sensitizes liver cancer to radioimmunotherapy.

As radiotherapy techniques improve so does the ability to more precisely target glioblastoma while sparing neighboring healthy tissue. Here, the authors present a prospective pilot study evaluating the feasibility of personalized precision radiation guided by machine-learning maps of estimated tumor infiltration and predicted recurrence in patients with newly diagnosed glioblastoma.

Radiotherapy (RT) is standard-of-care in cancer management; however, RT efficacy remains limited. Here, the authors test whether membrane camouflaged BCG bacteria (MBCG) enhance response to RT in preclinical models of glioblastoma. MBCG efficiently targets tumor tissues, induces trained immunity in tumor-associated macrophages, and enhances the RT-induced anti-tumor responses.

Adjuvant chemoradiotherapy has a proven survival benefit for patients undergoing upfront resection of gastric cancer compared with surgery alone. Now, data from the TOPGEAR trial demonstrate that adding radiotherapy to standard-of-care perioperative chemotherapy offers no additional survival benefit. I discuss the implications for treatment and future research.