Stem-cell research articles within Nature Materials

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• Article | 23 November 2020

  Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

  Extrusion-based bioprinting has been shown to rapidly and reproducibly generate kidney organoids from a cell-only paste, with the number and maturation of functional units within the kidney tissue capable of being further improved by bioprinting tissue sheets.

  • Kynan T. Lawlor
  • , Jessica M. Vanslambrouck
  •  & Melissa H. Little

• Article | 18 March 2019

  Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

  The extracellular matrix surrounding cells plays a significant role in their behaviour. The spreading, mechanosensing and differentiation of mesenchymal stem cells are shown to be dependent on the early deposition and remodelling of local nascent proteins within degradable and viscoelastic hydrogels.

  • Claudia Loebel
  • , Robert L. Mauck
  •  & Jason A. Burdick

• Article | 21 May 2018

  Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

  Mechanical cues play critical roles in embryonic development. A micropatterned neuroectoderm developmental model based on human pluripotent stem cells now reveals how morophogenetic signals such as cell shape and contractility regulate neural tissue development.

  • Xufeng Xue
  • , Yubing Sun
  •  & Jianping Fu