Stress and resilience articles from across Nature Portfolio

The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related to salt stress resistance in distal tissues.

Stress increases the intake of high-fat food, contributing to obesity and eating disorders. Here authors show, in mice, that stress impairs the control of the prefrontal cortex over feeding centers in the hypothalamus, driving excess fat intake.

Wang and colleagues used in vivo ATP imaging of retinal ganglion cells to determine the metabolic diversity across closely related neuron types. They found different homeostatic ATP levels and mitochondrial reliance for energy production that impacted survival after axon injury.

Disrupted dorsal raphe activity following early-life stress selectively impairs startle response habituation, despite broader behavioural consequences.

In this issue of Nature Metabolism, Sun et al. show that the kynurenine pathway of tryptophan metabolism links stress-induced impairment of immune surveillance to liver cancer progression.

Nature Reviews Psychology is interviewing people with lived experience of mental health challenges. We spoke with a volunteer from Anoiksis, a patient association for psychosis, about leading conversations about mental health.

This month’s issue is dedicated to laying out the multiple ways in which people with lived experience contribute to clinical research, what needs to be improved and how to do it.