T cells articles from across Nature Portfolio

A newly identified subset of CD4⁺ T cells is distinguished by increased expression of EOMES and granzyme K. These ‘T_HK’ cells are found in diverse immunological contexts and shown to mediate intestinal immunopathology.

Microsatellite-stable/proficient mismatch repair colorectal cancers are resistant to immune checkpoint blockade immunotherapy due to their immune suppressive tumour microenvironment. Here the authors show in mouse models that the transcription factor Arid3b contributes to the suppression of CD8 + T cell infiltration and activity in these tumours via suppressing Runx3, a known regulator of tissue resident memory phenotype in CD8 + T cells.

CD4⁺ T cells are key drivers of chronic inflammation and immune-mediated tissue damage in autoimmune diseases. Here, the authors employ a mouse model of primary Sjögren disease (pSjD) and identify a subset of CD153⁺ CD4⁺ T cells responsible for inflammation and autoimmunity through interactions with CD30⁺ resident fibroblasts, and demonstrate that targeting the CD153-CD30 axis alleviates disease pathology in mice.

Tsai and colleagues propose that BET inhibitors can blunt T cell exhaustion via a pathway involving ornithine decarboxylase-dependent polyamine biosynthesis.

Chimeric antigen receptor (CAR)-T cell therapy has been shown successful in a range of malignancies but due to an absence of notable antigenic targets has limited its application to acute myeloid leukaemia (AML). Here the authors identify CD84 as a potential target for AML and show that the application of CD84 CAR-T in models of AML results in reduced tumour burden and enhanced survival.

T cells integrate signals from self-ligands not only during thymic development but also as they circulate through secondary lymphoid organs. These encounters with self in the periphery shape their activation and function, thereby ‘training’ T cells to interpret and respond to foreign antigens.

HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.

CD8⁺ T cells infiltrating the kidneys contribute to lupus nephritis by retaining cytotoxic functions despite appearing to be terminally differentiated.

Findings reveal that stem-like CD8⁺ T cells migrate from renal lymph nodes and cause tissue damage in lupus nephritis.

A newly identified subset of CD4⁺ T cells is distinguished by increased expression of EOMES and granzyme K. These ‘T_HK’ cells are found in diverse immunological contexts and shown to mediate intestinal immunopathology.

Hu et al. report that activated T cells can enhance antigen processing and presentation in tumour cells and dendritic cells through DNA transfer by extracellular vesicles.

A preprint by Chen et al. identifies Dusp5 and Zfp219 as regulators of age-associated T cell dysfunction in the tumour microenvironment.