Tissue engineering articles from across Nature Portfolio

High-throughput and controlled organoid fabrication is achieved by combining 3D bioprinting, matrix biochemistry and stress relaxation in packed hydrogel particles.

Mechanotransduction involved in pathological tissue remodelling is recapitulated in vitro in a proof-of-concept microphysiological system of human asthmatic lungs.

Low retention of transplanted stem cells limits their clinical application. Here, the authors develop a nanoparticle-based strategy that increases cell density to enhance retention, improve tissue regeneration, and reduce fibrosis through modulation of cellular density and physical forces.

Poor vascularization and weak regenerative signaling limit tracheal repair. Here, the authors develop a mechanically-driven expandable patch to angiogenesis tracheal repair through electromechanical stimulation.

Engineered cardiac microtissues and modeling reveal that cardiomyocyte contraction prestretches collagen to drive tissue anisotropy, improving sarcomere development and contractility and informing cardiac regeneration strategies.

Early human heart development is shaped by biomechanical cues that are difficult to study in vivo. Here, authors engineer a perfusable 3D-bioprinted model of the embryonic heart tube for in vitro modelling of early human heart development.

Cell sheet engineering offers a scaffold-free approach to tissue reconstruction. This Review outlines fabrication methods, key mechanical design strategies and innovations aimed at enabling the use of cell sheets in mechanically demanding tissues.

High-throughput and controlled organoid fabrication is achieved by combining 3D bioprinting, matrix biochemistry and stress relaxation in packed hydrogel particles.

A tissue-engineered esophageal graft supports luminal patency in growing minipigs with emerging structural integration.

Human protein-based biomaterials facilitate the development of preclinical models that integrate predictive value and ethical responsibility. Metatissue uses decellularized extracellular matrix from placenta samples and human blood to create tunable, xeno-free substrates for 3D cell culture, minimizing the reliance on animal models and accelerating translational research.

Placental organoids offer powerful tools to advance diagnostics and therapies for pregnancy complications including preeclampsia and fetal growth restriction. However, most current models rely on animal-derived materials and heterogenous cell sources. Developing human-based physiologically relevant organoid models is essential to understand disease phenotypes and improve clinical care for high-risk pregnancies.

Four-dimensional bioprinting of tissues goes beyond cellular constructs that evolve or mature over time. It should incorporate time as an active design parameter, enabling programmed and predictable transformations. This requires implementing shape-morphing behaviour, either within materials or cell–matrix composites, to control the construct’s transition in form or size.

Two seminal studies report a bioengineering approach to modeling CAR-T cell therapy of solid human tumors.