Type 1 diabetes articles from across Nature Portfolio

This study demonstrates that cytoskeletal state at the onset of directed differentiation impacts the exit of stem cells from pluripotency and downstream lineage specification. These findings are utilized to improve stem cell-derived islet generation.

A trial emulation study using electronic health record data from 174,678 patients with type 1 diabetes revealed that GLP-1RA initiation is associated with reduced risk of major cardiovascular events and end-stage kidney disease.

Links between type 1 diabetes and neurocognitive traits remain unclear. Here, the authors integrate genetic and single‑cell epigenomic data to show brain‑cell, especially microglial, involvement and identify shared genetic mechanisms connecting diabetes with cognition and neuropsychiatric risk.

Histological analysis of the human pancreas provides insight into initiation and progression of type 1 diabetes (T1D). Here the authors utilize pancreatic tissue sections across different disease stages and apply whole slide imaging and digital pathology to identify endocrine cell composition, immune cell burden and spatial islet relationships in health and over the course of T1D.

For nearly three decades, my life has consisted of insulin injections, monitoring of glucose levels and emotional, mental and physical labour. Here, I share my experience of being a Black person living with type 1 diabetes mellitus, including cultural and systemic challenges that affected my access to the care I was entitled to.

Stem-cell-derived islet cells could transform type 1 diabetes by removing the need for injected or infused insulin and improving quality of life. But evaluation of these therapies must center on the voices of people living with type 1 diabetes and examine meaningful outcomes.

Children born to mothers with type 1 diabetes (T1D) are less likely to develop T1D than those with an affected father or sibling. We identified modifications of DNA methylation at multiple T1D risk genes in blood samples from children exposed to maternal T1D. These changes were linked to decreased islet autoimmunity risk.