Surgical management of anterior lenticonus in Alport’s syndrome

Sir,

Alport’s syndrome is a rare basement membrane disorder characterized by progressive hereditary nephritis, sensorineural hearing loss and ocular abnormalities. The inheritance is predominantly X-linked (85%), although it can be autosomal recessive (10%) or autosomal dominant (5%).¹ Homozygote males are usually severely affected but females tend to have a mild form, often with only microscopic haematuria and normal renal function.¹ The ocular abnormalities in the X-linked form are characteristically a dot-and-fleck retinopathy, less often anterior lenticonus and rarely a posterior polymorphous corneal dystrophy.^1,2 Additional ocular abnormalities are not uncommon, including cataracts, posterior lenticonus and retinal detachment.²

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD