Tubulo-interstitial nephritis and uveitis with bilateral optic disc oedema

Sir,

Tubulo-interstitial nephritis and uveitis (TINU) is an uncommon oculo-renal disorder of immune origin. It is more common in female adolescents (3:1 female to male ratio). The uveitis is typically bilateral, anterior, nongranulomatous and may occur before, simultaneously or after the onset of the nephritis. Renal involvement is in the form of acute interstitial nephritis (AIN) and it remains unclear whether it is secondary to infection, drug induced or idiopathic.¹ The nephritis is usually self-limited but the uveitis tends to become recurrent.^2,3 In these cases where there is no response to topical treatment, systemic steroids or even second-line immunosuppression may have a beneficial effect in controlling the anterior uveitis and improving renal function.^2,3

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