Retinal pigment epithelium tear after intravitreal bevacizumab injection for polypoidal choroidal vasculopathy

Peng, C-H; Cheng, C-K; Chiou, S-H

doi:10.1038/eye.2008.401

Correspondence
Published: 23 January 2009

Retinal pigment epithelium tear after intravitreal bevacizumab injection for polypoidal choroidal vasculopathy

C-H Peng^1,2,3,4,
C-K Cheng^1,2,5 &
S-H Chiou⁶

Eye volume 23, pages 2126–2129 (2009)Cite this article

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Sir,

A retinal pigment epithelium (RPE) tear is a well-recognized complication of pigment epithelial detachments (PEDs) in age-related macular degeneration (AMD), as well as in polypoidal choroidal vasculopathy (PCV).¹ Recently, several reports have recognized that an RPE tear can occur after anti-vascular endothelial growth factor (VEGF) therapy such as bevacizumab, ranibizumab, and pegaptanib for AMD.² In this report, we present a patient with PCV who developed an RPE tear after an intravitreal bevacizumab injection. On the basis of serial findings of optical coherence tomography, a possible mechanism was suggested as being responsible for the formation of RPE tears.

References

Tsujikawa A, Hirami Y, Nakanishi H, Ojima Y, Aikawa H, Tamura H et al. Retinal pigment epithelial tear in polypoidal choroidal vasculopathy. Retina 2007; 27: 832–838.
Article Google Scholar
Chang LK, Sarraf D . Tears of the retinal pigment epithelium: an old problem in a new era. Retina 2007; 27: 523–534.
Article Google Scholar
Chan CK, Meyer CH, Gross JG, Abraham P, Nuthi AS, Kokame GT et al. Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina 2007; 27: 541–551.
Article Google Scholar
Pauleikhoff D, Löffert D, Spital G, Radermacher M, Dohrmann J, Lommatzsch A et al. Pigment epithelial detachment in the elderly. Clinical differentiation, natural course and pathogenetic implications. Graefes Arch Clin Exp Ophthalmol 2002; 240: 533–538.
Article CAS Google Scholar
Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Oshima Y, Kamei M et al. Efficacy of Intravitreal bevacizumab for polypoidal choroidal vasculopathy. Br J Ophthalmol 2008; 92: 70–73.
Article CAS Google Scholar
Chuang EL, Bird AC . The pathogenesis of tears of the retinal pigment epithelium. Am J Ophthalmol 1988; 105: 285–290.
Article CAS Google Scholar
Gass JD . Pathogenesis of tears of the retinal pigment epithelium. Br J Ophthalmol 1984; 68: 513–519.
Article CAS Google Scholar
Hartnett ME, Lappas A, Darland D, McColm JR, Lovejoy S, D'Amore PA . Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp Eye Res 2003; 77: 593–599.
Article CAS Google Scholar
Leitritz M, Gelisken F, Inhoffen W, Voelker M, Ziemssen F . Can the risk of retinal pigment epithelium tears after bevacizumab treatment be predicted? An optical coherence tomography study. Eye 2008; 22: 1504–1507.
Article CAS Google Scholar

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Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
C-H Peng & C-K Cheng
School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
C-H Peng & C-K Cheng
School of Medicine, National Yang-Ming University, Taipei, Taiwan
C-H Peng
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
C-H Peng
School of Medicine, National Taiwan University, Taipei, Taiwan
C-K Cheng
Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
S-H Chiou

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C-H Peng
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C-K Cheng
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S-H Chiou
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Correspondence to C-K Cheng.

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Peng, CH., Cheng, CK. & Chiou, SH. Retinal pigment epithelium tear after intravitreal bevacizumab injection for polypoidal choroidal vasculopathy. Eye 23, 2126–2129 (2009). https://doi.org/10.1038/eye.2008.401

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Published: 23 January 2009
Issue date: November 2009
DOI: https://doi.org/10.1038/eye.2008.401

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Retinal pigment epithelium tear after intravitreal bevacizumab injection for polypoidal choroidal vasculopathy

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Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab

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