Abstract
Adaptive optics imaging of cone photoreceptors has provided unique insight into the structure and function of the human visual system and has become an important tool for both basic scientists and clinicians. Recent advances in adaptive optics retinal imaging instrumentation and methodology have allowed us to expand beyond cone imaging. Multi-wavelength and fluorescence imaging methods with adaptive optics have allowed multiple retinal cell types to be imaged simultaneously. These new methods have recently revealed rod photoreceptors, retinal pigment epithelium (RPE) cells, and the smallest retinal blood vessels. Fluorescence imaging coupled with adaptive optics has been used to examine ganglion cells in living primates. Two-photon imaging combined with adaptive optics can evaluate photoreceptor function non-invasively in the living primate retina.
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Acknowledgements
This work was supported by: NIH Grants EY014375, EY004367, & EY007125. Alfredo Dubra-Suarez, PhD, holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.
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David Williams and Alfredo Dubra are inventors on patents held by the University of Rochester in the field of ophthalmoscopy and high-resolution retinal imaging with adaptive optics.
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This work was presented at the 2010 Cambridge Ophthalmological Symposium
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Rossi, E., Chung, M., Dubra, A. et al. Imaging retinal mosaics in the living eye. Eye 25, 301–308 (2011). https://doi.org/10.1038/eye.2010.221
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DOI: https://doi.org/10.1038/eye.2010.221
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